diff --git a/src/google/protobuf/compiler/cpp/helpers.h b/src/google/protobuf/compiler/cpp/helpers.h
index 15e51d0..89dd225 100644
--- a/src/google/protobuf/compiler/cpp/helpers.h
+++ b/src/google/protobuf/compiler/cpp/helpers.h
@@ -872,7 +872,18 @@
 inline std::string WeakDefaultInstanceSection(const Descriptor* descriptor,
                                               int index_in_file_messages,
                                               const Options& options) {
-  return WeakDescriptorDataSection("def", descriptor, index_in_file_messages,
+#ifdef PROTOBUF_MESSAGE_GLOBALS
+  std::string prefix = !IsProfileDriven(options)               ? "def"
+                       : IsPresentMessage(descriptor, options) ? "gh"
+                                                               : "gl";
+#else
+  std::string prefix = "def";
+#endif
+  // TODO: b/474609573 - Remove WeakDescriptorDataSection() once
+  // PROTOBUF_MESSAGE_GLOBALS becomes the default. Note that section assignment
+  // is nuanced to maximize the spatial locality and to support weak descriptor
+  // GC. The status quo is vulnerable to suboptimal prefix.
+  return WeakDescriptorDataSection(prefix, descriptor, index_in_file_messages,
                                    options);
 }
 
diff --git a/src/google/protobuf/compiler/cpp/message.cc b/src/google/protobuf/compiler/cpp/message.cc
index cd0768c..82fc024 100644
--- a/src/google/protobuf/compiler/cpp/message.cc
+++ b/src/google/protobuf/compiler/cpp/message.cc
@@ -5633,8 +5633,12 @@
                  // File descriptor proto is mutable.
                  if (is_file_descriptor_proto) return;
 
-                 p->Emit(
-                     R"cc(PROTOBUF_MESSAGE_GLOBALS_SECTION(.data.rel.ro))cc");
+                 p->Emit({{"section_name",
+                           !IsProfileDriven(options_) ||
+                                   IsPresentMessage(descriptor_, options_)
+                               ? ".data.rel.ro"
+                               : ".data.rel.ro.unlikely"}},
+                         "PROTOBUF_MESSAGE_GLOBALS_SECTION($section_name$)");
                }})
               .WithSuffix(""),
           {