Linux on Alpha has the configuration name linux-alpha-gcc, not
linux-alpha.

openssl.spec

diff --git a/openssl.spec b/openssl.spec
index 18ae94e..fa8c16b 100644
--- a/openssl.spec
+++ b/openssl.spec
@@ -94,7 +94,7 @@
 ./Configure %{CONFIG_FLAGS} --openssldir=%{openssldir} linux-ppc shared
 %endif
 %ifarch alpha
-./Configure %{CONFIG_FLAGS} --openssldir=%{openssldir} linux-alpha shared
+./Configure %{CONFIG_FLAGS} --openssldir=%{openssldir} linux-alpha-gcc shared
 %endif
 LD_LIBRARY_PATH=`pwd` make
 LD_LIBRARY_PATH=`pwd` make rehash